How virus assembles spontaneously remains one of the greatest unanswered questions of physical virology. A number of methods, such as small angle X-ray and neutron scattering, electron and light microscopy have been applied to try and understand this fundamental process. We examine the thermodynamic equilibrium and kinetics of assembly by light scattering, fluorescence measurements of the amount of proteins bound in a shell around the template and by in vitro single particle imaging.
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